Drug interactions
Axitinib + Dasatinib
Severity: Minor
Axitinib and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and axitinib is metabolized mainly by CYP3A4, so axitinib exposure may rise modestly. This could increase hypertension, diarrhea and other adverse effects.
What this interaction means in plain words
Axitinib and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Dasatinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated axitinib metabolism by dasatinib.
What to do
Monitor blood pressure and tolerability, and adjust the axitinib dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Dasatinib?
MediHelp rates the interaction as minor. Axitinib and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and axitinib is metabolized mainly by CYP3A4, so axitinib exposure may rise modestly. This could increase hypertension, diarrhea and other adverse effects.
How serious is the interaction between Axitinib and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and adjust the axitinib dose if adverse effects occur.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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