Drug interactions
Axitinib + Dronedarone
Severity: Moderate
Axitinib and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and may increase axitinib exposure. This raises the risk of hypertension, diarrhea and other axitinib toxicities.
What this interaction means in plain words
Axitinib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4 metabolism of axitinib.
What to do
Monitor blood pressure and tolerability closely and reduce the axitinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Dronedarone?
MediHelp rates the interaction as moderate. Axitinib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and may increase axitinib exposure. This raises the risk of hypertension, diarrhea and other axitinib toxicities.
How serious is the interaction between Axitinib and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability closely and reduce the axitinib dose if toxicity develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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