Drug interactions
Axitinib + Eslicarbazepine
Severity: Moderate
Axitinib and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may reduce axitinib exposure. This may decrease antitumor efficacy.
What this interaction means in plain words
Axitinib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Eslicarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by eslicarbazepine increases axitinib metabolism.
What to do
Prefer a non-inducing antiseizure drug. If combined, monitor tumor response and blood pressure for signs of reduced axitinib exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Eslicarbazepine?
MediHelp rates the interaction as moderate. Axitinib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may reduce axitinib exposure. This may decrease antitumor efficacy.
How serious is the interaction between Axitinib and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug. If combined, monitor tumor response and blood pressure for signs of reduced axitinib exposure.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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