Drug interactions
Axitinib + Fluvoxamine
Severity: Minor
Axitinib and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP3A4 only weakly, so axitinib exposure may rise modestly. Axitinib is metabolized mainly by CYP3A4/5, and higher levels could increase hypertension, diarrhea or fatigue.
What this interaction means in plain words
Axitinib and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by fluvoxamine reduces axitinib clearance.
What to do
No empirical dose change is needed; monitor blood pressure and tolerability of axitinib and reduce the dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Fluvoxamine?
MediHelp rates the interaction as minor. Axitinib and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine inhibits CYP3A4 only weakly, so axitinib exposure may rise modestly. Axitinib is metabolized mainly by CYP3A4/5, and higher levels could increase hypertension, diarrhea or fatigue.
How serious is the interaction between Axitinib and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor blood pressure and tolerability of axitinib and reduce the dose if adverse effects develop.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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