Drug interactions
Axitinib + Fosaprepitant
Severity: Moderate
Axitinib and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor and may transiently raise axitinib exposure. The effect is usually modest after a single dose.
What this interaction means in plain words
Axitinib and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, reducing axitinib metabolism.
What to do
Monitor blood pressure and tolerability around fosaprepitant dosing, and reduce the axitinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Axitinib with Fosaprepitant?
MediHelp rates the interaction as moderate. Axitinib and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor and may transiently raise axitinib exposure. The effect is usually modest after a single dose.
How serious is the interaction between Axitinib and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability around fosaprepitant dosing, and reduce the axitinib dose if adverse effects occur.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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