Drug interactions
Axitinib + Lurasidone
Severity: Minor
Axitinib and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is a weak CYP3A4 inhibitor in vitro, and its clinical effect on lurasidone is unlikely to be large. Lurasidone is a sensitive CYP3A4 substrate, so a modest rise in exposure is theoretically possible. Also, lurasidone is not expected to meaningfully change axitinib levels.
What this interaction means in plain words
Axitinib and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Theoretical weak CYP3A4 inhibition by axitinib reducing lurasidone clearance.
What to do
No dose adjustment is usually needed. Monitor for lurasidone adverse effects such as akathisia, sedation and parkinsonism.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Lurasidone?
MediHelp rates the interaction as minor. Axitinib and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is a weak CYP3A4 inhibitor in vitro, and its clinical effect on lurasidone is unlikely to be large. Lurasidone is a sensitive CYP3A4 substrate, so a modest rise in exposure is theoretically possible. Also, lurasidone is not expected to meaningfully change axitinib levels.
How serious is the interaction between Axitinib and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for lurasidone adverse effects such as akathisia, sedation and parkinsonism.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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