Drug interactions
Axitinib + Midazolam
Severity: Minor
Axitinib and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a CYP3A4 substrate and is not a clinically meaningful inhibitor of CYP3A4 at usual doses, so a significant rise in axitinib levels is not expected. Axitinib is not known to meaningfully alter midazolam either, so the interaction is not well supported.
What this interaction means in plain words
Axitinib and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
No well-established mechanism; both are CYP3A4 substrates and competition is unlikely to matter clinically.
What to do
No dose adjustment is needed; monitor for usual adverse effects of each drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Midazolam?
MediHelp rates the interaction as minor. Axitinib and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam is a CYP3A4 substrate and is not a clinically meaningful inhibitor of CYP3A4 at usual doses, so a significant rise in axitinib levels is not expected. Axitinib is not known to meaningfully alter midazolam either, so the interaction is not well supported.
How serious is the interaction between Axitinib and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for usual adverse effects of each drug.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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