Drug interactions
Azacitidine + Dichlorphenamide
Severity: Moderate
Azacitidine and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide lowers serum potassium and bicarbonate, and azacitidine can cause hypokalemia and renal tubular acidosis. Together they may worsen electrolyte and acid-base disturbance.
What this interaction means in plain words
Azacitidine and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive potassium loss and acidosis, with a plausible renal tubular contribution from azacitidine.
What to do
Monitor serum potassium and bicarbonate at baseline and during therapy. Correct hypokalemia and review the need for dichlorphenamide if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Azacitidine
- Azacitidine + Fingolimod Major
- Azacitidine + Siponimod Major
- Azacitidine + Denosumab Moderate
- Azacitidine + Hydroxyurea Moderate
- Azacitidine + Trastuzumab Moderate
Frequently asked questions
Can I take Azacitidine with Dichlorphenamide?
MediHelp rates the interaction as moderate. Azacitidine and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide lowers serum potassium and bicarbonate, and azacitidine can cause hypokalemia and renal tubular acidosis. Together they may worsen electrolyte and acid-base disturbance.
How serious is the interaction between Azacitidine and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and during therapy. Correct hypokalemia and review the need for dichlorphenamide if acidosis develops.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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