Drug interactions
Azacitidine + Trastuzumab
Severity: Moderate
Azacitidine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azacitidine is myelosuppressive, and trastuzumab has been associated with higher rates of neutropenia and febrile neutropenia when combined with myelosuppressive chemotherapy. The combination may increase infection risk.
What this interaction means in plain words
Azacitidine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity; trastuzumab may worsen chemotherapy-induced neutropenia by an incompletely understood mechanism.
What to do
Monitor complete blood counts regularly and watch for fever or infection; manage neutropenia per standard protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Azacitidine
- Azacitidine + Fingolimod Major
- Azacitidine + Siponimod Major
- Azacitidine + Denosumab Moderate
- Azacitidine + Dichlorphenamide Moderate
- Azacitidine + Hydroxyurea Moderate
Frequently asked questions
Can I take Azacitidine with Trastuzumab?
MediHelp rates the interaction as moderate. Azacitidine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azacitidine is myelosuppressive, and trastuzumab has been associated with higher rates of neutropenia and febrile neutropenia when combined with myelosuppressive chemotherapy. The combination may increase infection risk.
How serious is the interaction between Azacitidine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for fever or infection; manage neutropenia per standard protocols.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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