Drug interactions
Azacitidine + Hydroxyurea
Severity: Moderate
Azacitidine and Hydroxyurea: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow function. Used together they can deepen neutropenia, anemia and thrombocytopenia, raising the risk of infection and bleeding.
What this interaction means in plain words
Azacitidine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts regularly and adjust doses or delay cycles for significant cytopenias. Provide supportive care as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyurea
Other interactions of Azacitidine
- Azacitidine + Fingolimod Major
- Azacitidine + Siponimod Major
- Azacitidine + Denosumab Moderate
- Azacitidine + Dichlorphenamide Moderate
- Azacitidine + Trastuzumab Moderate
Frequently asked questions
Can I take Azacitidine with Hydroxyurea?
MediHelp rates the interaction as moderate. Azacitidine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow function. Used together they can deepen neutropenia, anemia and thrombocytopenia, raising the risk of infection and bleeding.
How serious is the interaction between Azacitidine and Hydroxyurea?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or delay cycles for significant cytopenias. Provide supportive care as needed.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
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