Drug interactions
Azathioprine + Benazepril
Severity: Moderate
Azathioprine and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors have been associated with anemia and leukopenia when given with azathioprine, particularly in patients with renal impairment. The risk of severe myelosuppression may be increased.
What this interaction means in plain words
Azathioprine and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Benazepril belongs to Cardiovascular.
Why it happens
Possible additive bone marrow suppression, as ACE inhibition may lower erythropoietin and affect marrow function.
What to do
Monitor complete blood counts regularly, especially at the start of therapy or after dose changes. Reduce azathioprine dose or stop either drug if leukopenia or anemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Azathioprine with Benazepril?
MediHelp rates the interaction as moderate. Azathioprine and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors have been associated with anemia and leukopenia when given with azathioprine, particularly in patients with renal impairment. The risk of severe myelosuppression may be increased.
How serious is the interaction between Azathioprine and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, especially at the start of therapy or after dose changes. Reduce azathioprine dose or stop either drug if leukopenia or anemia develops.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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