Drug interactions
Azelastine + Clobazam
Severity: Moderate
Azelastine and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine that causes sedation, and azelastine may add to drowsiness and psychomotor impairment. Excess CNS and respiratory depression can occur, particularly with higher doses or other depressants.
What this interaction means in plain words
Azelastine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 antagonism.
What to do
Monitor for oversedation and respiratory depression. Advise patients to avoid alcohol and driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Azelastine with Clobazam?
MediHelp rates the interaction as moderate. Azelastine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine that causes sedation, and azelastine may add to drowsiness and psychomotor impairment. Excess CNS and respiratory depression can occur, particularly with higher doses or other depressants.
How serious is the interaction between Azelastine and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression. Advise patients to avoid alcohol and driving until response is known.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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