Drug interactions
Azelastine + Clomipramine
Severity: Moderate
Azelastine and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a sedating, anticholinergic tricyclic antidepressant, and azelastine may add to drowsiness. The combination may increase sedation, dizziness and impaired psychomotor performance.
What this interaction means in plain words
Azelastine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-receptor antagonism and tricyclic antihistaminic and anticholinergic activity.
What to do
Counsel on additive sedation and avoid driving until tolerance is established. Monitor older patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Azelastine with Clomipramine?
MediHelp rates the interaction as moderate. Azelastine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a sedating, anticholinergic tricyclic antidepressant, and azelastine may add to drowsiness. The combination may increase sedation, dizziness and impaired psychomotor performance.
How serious is the interaction between Azelastine and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving until tolerance is established. Monitor older patients for confusion and falls.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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