Drug interactions
Azelastine + Clorazepate
Severity: Moderate
Azelastine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine, particularly as a nasal spray with some systemic absorption, can cause drowsiness. Combined with the benzodiazepine clorazepate, sedation and psychomotor impairment may be greater than with either drug alone.
What this interaction means in plain words
Azelastine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Clorazepate belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from the sedating antihistamine and the benzodiazepine.
What to do
Warn the patient about increased drowsiness and advise against driving or operating machinery until the response is known. Avoid alcohol and consider lowering the clorazepate dose if excessive sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azelastine and Clorazepate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azelastine
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Azelastine with Clorazepate?
MediHelp rates the interaction as moderate. Azelastine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine, particularly as a nasal spray with some systemic absorption, can cause drowsiness. Combined with the benzodiazepine clorazepate, sedation and psychomotor impairment may be greater than with either drug alone.
How serious is the interaction between Azelastine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about increased drowsiness and advise against driving or operating machinery until the response is known. Avoid alcohol and consider lowering the clorazepate dose if excessive sedation develops.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
