Drug interactions
Azelastine + Flibanserin
Severity: Moderate
Azelastine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin is metabolized mainly by CYP3A4, and its exposure rises with CYP3A4 inhibitors. Azelastine is not a recognized meaningful CYP3A4 inhibitor, but flibanserin also causes sedation, hypotension and syncope, which may be added to by azelastine's drowsiness.
What this interaction means in plain words
Azelastine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depression; any CYP3A4 inhibition by azelastine is weak and not well established.
What to do
Counsel the patient about drowsiness, dizziness and avoiding alcohol. Monitor for excessive sedation or hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Azelastine with Flibanserin?
MediHelp rates the interaction as moderate. Azelastine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin is metabolized mainly by CYP3A4, and its exposure rises with CYP3A4 inhibitors. Azelastine is not a recognized meaningful CYP3A4 inhibitor, but flibanserin also causes sedation, hypotension and syncope, which may be added to by azelastine's drowsiness.
How serious is the interaction between Azelastine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness, dizziness and avoiding alcohol. Monitor for excessive sedation or hypotension.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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