Drug interactions
Azelastine + Fluphenazine
Severity: Moderate
Azelastine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is an antipsychotic with sedative effects. With azelastine, drowsiness and reduced alertness may increase.
What this interaction means in plain words
Azelastine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 antagonism and central dopamine blockade.
What to do
Monitor for excessive sedation and advise against driving until response is known. Reduce doses or choose a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Azelastine with Fluphenazine?
MediHelp rates the interaction as moderate. Azelastine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is an antipsychotic with sedative effects. With azelastine, drowsiness and reduced alertness may increase.
How serious is the interaction between Azelastine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise against driving until response is known. Reduce doses or choose a non-sedating antihistamine if needed.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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