Drug interactions
Azelastine + Hydroxyzine
Severity: Moderate
Azelastine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine, so combination with azelastine increases drowsiness and anticholinergic effects. Hydroxyzine also carries a QT risk, though azelastine adds little to this.
What this interaction means in plain words
Azelastine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Hydroxyzine belongs to Respiratory.
Why it happens
Additive H1-antihistamine mediated CNS depression.
What to do
Avoid duplicate antihistamine use where possible and counsel against driving. Monitor older patients for confusion and oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Azelastine with Hydroxyzine?
MediHelp rates the interaction as moderate. Azelastine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine, so combination with azelastine increases drowsiness and anticholinergic effects. Hydroxyzine also carries a QT risk, though azelastine adds little to this.
How serious is the interaction between Azelastine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antihistamine use where possible and counsel against driving. Monitor older patients for confusion and oversedation.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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