Drug interactions
Azelastine + Iloperidone
Severity: Moderate
Azelastine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, and iloperidone also causes orthostatic hypotension and dizziness. Their combination can increase drowsiness and impair alertness.
What this interaction means in plain words
Azelastine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 antagonism and antipsychotic receptor blockade.
What to do
Monitor for sedation and orthostatic symptoms. Counsel on driving and machinery use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Azelastine with Iloperidone?
MediHelp rates the interaction as moderate. Azelastine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, and iloperidone also causes orthostatic hypotension and dizziness. Their combination can increase drowsiness and impair alertness.
How serious is the interaction between Azelastine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms. Counsel on driving and machinery use.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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