Drug interactions
Azelastine + Ivacaftor
Severity: Minor
Azelastine and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a CYP3A4 substrate, and inhibitors can raise its exposure. Azelastine is at most a weak inhibitor and systemic exposure from the nasal spray is low, so a clinically relevant rise is unlikely.
What this interaction means in plain words
Azelastine and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Ivacaftor belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 inhibition reducing ivacaftor clearance.
What to do
No routine adjustment is needed. Monitor for ivacaftor adverse effects such as raised transaminases or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Azelastine with Ivacaftor?
MediHelp rates the interaction as minor. Azelastine and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a CYP3A4 substrate, and inhibitors can raise its exposure. Azelastine is at most a weak inhibitor and systemic exposure from the nasal spray is low, so a clinically relevant rise is unlikely.
How serious is the interaction between Azelastine and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for ivacaftor adverse effects such as raised transaminases or headache.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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