Drug interactions
Azelastine + Lomitapide
Severity: Moderate
Azelastine and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is extensively metabolized by CYP3A4 and its exposure rises with inhibitors, increasing the risk of hepatotoxicity and gastrointestinal effects. Azelastine is at most a weak inhibitor, but caution is warranted given lomitapide's narrow margin.
What this interaction means in plain words
Azelastine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Lomitapide belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition reducing lomitapide clearance.
What to do
Monitor liver enzymes per the lomitapide monitoring schedule and keep the dose within labeled limits for weak inhibitors. Review the need for azelastine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Azelastine with Lomitapide?
MediHelp rates the interaction as moderate. Azelastine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is extensively metabolized by CYP3A4 and its exposure rises with inhibitors, increasing the risk of hepatotoxicity and gastrointestinal effects. Azelastine is at most a weak inhibitor, but caution is warranted given lomitapide's narrow margin.
How serious is the interaction between Azelastine and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes per the lomitapide monitoring schedule and keep the dose within labeled limits for weak inhibitors. Review the need for azelastine.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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