Drug interactions
Azelastine + Nabilone
Severity: Moderate
Azelastine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone causes drowsiness, dizziness and cognitive effects, which may be potentiated by azelastine. Alertness and judgment may be notably reduced.
What this interaction means in plain words
Azelastine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from H1-receptor antagonism and cannabinoid receptor agonism.
What to do
Monitor for oversedation and confusion. Advise against driving and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Nabilone
Frequently asked questions
Can I take Azelastine with Nabilone?
MediHelp rates the interaction as moderate. Azelastine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone causes drowsiness, dizziness and cognitive effects, which may be potentiated by azelastine. Alertness and judgment may be notably reduced.
How serious is the interaction between Azelastine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and confusion. Advise against driving and avoid alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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