Drug interactions
Azelastine + Perphenazine
Severity: Moderate
Azelastine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so concurrent use can increase drowsiness and impair concentration and coordination. Older adults are at greater risk of falls and confusion.
What this interaction means in plain words
Azelastine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism of azelastine and the antihistaminic, antidopaminergic and anticholinergic effects of perphenazine.
What to do
Monitor for excessive sedation and warn patients about driving and alcohol. Prefer a non-sedating antihistamine if an antihistamine is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Azelastine with Perphenazine?
MediHelp rates the interaction as moderate. Azelastine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so concurrent use can increase drowsiness and impair concentration and coordination. Older adults are at greater risk of falls and confusion.
How serious is the interaction between Azelastine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and warn patients about driving and alcohol. Prefer a non-sedating antihistamine if an antihistamine is required.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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