Drug interactions
Azelastine + Tapentadol
Severity: Moderate
Azelastine and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with sedating antihistamines can increase drowsiness, dizziness and psychomotor impairment, and may add to respiratory depression. The risk rises with higher doses, oral azelastine and other depressants.
What this interaction means in plain words
Azelastine and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and H1 antagonism.
What to do
Monitor sedation and respiratory status, using the lowest effective doses. Counsel patients to avoid alcohol and driving after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Frequently asked questions
Can I take Azelastine with Tapentadol?
MediHelp rates the interaction as moderate. Azelastine and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids combined with sedating antihistamines can increase drowsiness, dizziness and psychomotor impairment, and may add to respiratory depression. The risk rises with higher doses, oral azelastine and other depressants.
How serious is the interaction between Azelastine and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, using the lowest effective doses. Counsel patients to avoid alcohol and driving after dose changes.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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