Drug interactions
Azelastine-fluticasone + Caffeine
Severity: Minor
Azelastine-fluticasone and Caffeine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a stimulant that may counter some drowsiness caused by azelastine. There is no significant clinical interaction and no safety concern.
What this interaction means in plain words
Azelastine-fluticasone and Caffeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Caffeine belongs to Miscellaneous.
Why it happens
Opposing pharmacodynamic effects on alertness via adenosine receptor antagonism versus H1 blockade.
What to do
No action is required. Do not rely on caffeine to offset sedation when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Caffeine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Caffeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is a stimulant that may counter some drowsiness caused by azelastine. There is no significant clinical interaction and no safety concern.
How serious is the interaction between Azelastine-fluticasone and Caffeine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required. Do not rely on caffeine to offset sedation when driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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