Drug interactions
Azelastine-fluticasone + Chlorpheniramine
Severity: Moderate
Azelastine-fluticasone and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a first-generation sedating antihistamine, and using it with azelastine duplicates antihistamine therapy. This may increase sedation and anticholinergic effects.
What this interaction means in plain words
Azelastine-fluticasone and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Chlorpheniramine belongs to Respiratory.
Why it happens
Duplicate H1-receptor antagonism with additive central nervous system depression.
What to do
Avoid combining two antihistamines unless clearly needed. Monitor for drowsiness and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Azelastine-fluticasone with Chlorpheniramine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a first-generation sedating antihistamine, and using it with azelastine duplicates antihistamine therapy. This may increase sedation and anticholinergic effects.
How serious is the interaction between Azelastine-fluticasone and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antihistamines unless clearly needed. Monitor for drowsiness and anticholinergic effects.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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