Drug interactions
Azelastine-fluticasone + Chlorzoxazone
Severity: Moderate
Azelastine-fluticasone and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a sedating muscle relaxant, and azelastine can add drowsiness. Combined use may increase dizziness and impair alertness.
What this interaction means in plain words
Azelastine-fluticasone and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Monitor for sedation and warn patients about driving. Lower doses if impairment appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Azelastine-fluticasone with Chlorzoxazone?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a sedating muscle relaxant, and azelastine can add drowsiness. Combined use may increase dizziness and impair alertness.
How serious is the interaction between Azelastine-fluticasone and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and warn patients about driving. Lower doses if impairment appears.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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