Drug interactions
Azelastine-fluticasone + Cimetidine
Severity: Minor
Azelastine-fluticasone and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine given with azelastine has been shown to raise azelastine blood levels. This may increase azelastine adverse effects such as bitter taste and drowsiness, though the nasal route limits the overall exposure.
What this interaction means in plain words
Azelastine-fluticasone and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits hepatic CYP-mediated metabolism of azelastine, increasing its systemic exposure.
What to do
No routine dose change is needed. Watch for increased drowsiness and consider ranitidine-type or other non-inhibiting acid suppressants if problems occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Azelastine-fluticasone with Cimetidine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine given with azelastine has been shown to raise azelastine blood levels. This may increase azelastine adverse effects such as bitter taste and drowsiness, though the nasal route limits the overall exposure.
How serious is the interaction between Azelastine-fluticasone and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased drowsiness and consider ranitidine-type or other non-inhibiting acid suppressants if problems occur.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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