Drug interactions
Azelastine-fluticasone + Doxepin
Severity: Moderate
Azelastine-fluticasone and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong H1-blocking activity, so it adds to azelastine's sedative effect. Combined use may increase drowsiness, impaired psychomotor performance and anticholinergic effects.
What this interaction means in plain words
Azelastine-fluticasone and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression from H1-receptor antagonism.
What to do
Counsel on sedation and avoidance of driving until the response is known. Monitor for excessive sedation and anticholinergic effects, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Doxepin?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong H1-blocking activity, so it adds to azelastine's sedative effect. Combined use may increase drowsiness, impaired psychomotor performance and anticholinergic effects.
How serious is the interaction between Azelastine-fluticasone and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoidance of driving until the response is known. Monitor for excessive sedation and anticholinergic effects, especially in older adults.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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