Drug interactions
Azelastine-fluticasone + Isavuconazonium
Severity: Moderate
Azelastine-fluticasone and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluticasone is a CYP3A4 substrate and isavuconazole is a moderate CYP3A4 inhibitor, so fluticasone exposure may rise. The legacy note describes azelastine as raising isavuconazonium levels, which is not clinically meaningful.
What this interaction means in plain words
Azelastine-fluticasone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4, reducing the metabolism of fluticasone and increasing systemic corticosteroid exposure.
What to do
Monitor for corticosteroid adverse effects such as adrenal suppression with prolonged use. Consider a less CYP3A4-dependent corticosteroid for long courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Isavuconazonium?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluticasone is a CYP3A4 substrate and isavuconazole is a moderate CYP3A4 inhibitor, so fluticasone exposure may rise. The legacy note describes azelastine as raising isavuconazonium levels, which is not clinically meaningful.
How serious is the interaction between Azelastine-fluticasone and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as adrenal suppression with prolonged use. Consider a less CYP3A4-dependent corticosteroid for long courses.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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