Drug interactions
Azelastine-fluticasone + Lemborexant
Severity: Minor
Azelastine-fluticasone and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Weak CYP3A4 inhibition by azelastine could raise lemborexant levels, although systemic exposure from the nasal spray is limited. Greater lemborexant exposure may cause next-day somnolence and impaired psychomotor performance. Azelastine itself is also sedating.
What this interaction means in plain words
Azelastine-fluticasone and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition reduces lemborexant clearance, with additive sedative effects.
What to do
Counsel on next-day drowsiness and driving risk. Use the lowest effective lemborexant dose and reduce it if daytime sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Lemborexant
Frequently asked questions
Can I take Azelastine-fluticasone with Lemborexant?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Weak CYP3A4 inhibition by azelastine could raise lemborexant levels, although systemic exposure from the nasal spray is limited. Greater lemborexant exposure may cause next-day somnolence and impaired psychomotor performance. Azelastine itself is also sedating.
How serious is the interaction between Azelastine-fluticasone and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on next-day drowsiness and driving risk. Use the lowest effective lemborexant dose and reduce it if daytime sedation occurs.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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