Drug interactions
Azelastine-fluticasone + Loxapine
Severity: Moderate
Azelastine-fluticasone and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine nasal spray can cause drowsiness in some patients, and loxapine is a sedating antipsychotic. Using them together may deepen sedation and impair alertness and psychomotor performance.
What this interaction means in plain words
Azelastine-fluticasone and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from the antihistaminic action of azelastine and the sedating antipsychotic effect of loxapine.
What to do
Counsel the patient about additive drowsiness and advise against driving or operating machinery until the response is known. If sedation is excessive, consider a non-sedating nasal option such as fluticasone alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Loxapine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine nasal spray can cause drowsiness in some patients, and loxapine is a sedating antipsychotic. Using them together may deepen sedation and impair alertness and psychomotor performance.
How serious is the interaction between Azelastine-fluticasone and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and advise against driving or operating machinery until the response is known. If sedation is excessive, consider a non-sedating nasal option such as fluticasone alone.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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