Drug interactions
Azelastine-fluticasone + Maprotiline
Severity: Moderate
Azelastine-fluticasone and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant with antihistaminic and anticholinergic activity. Combined with azelastine, which can cause drowsiness, the sedative effect may be increased and psychomotor performance impaired.
What this interaction means in plain words
Azelastine-fluticasone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-receptor antagonism by both drugs.
What to do
Counsel the patient on additive drowsiness and avoidance of driving or hazardous tasks until tolerance is established. Consider fluticasone alone if sedation is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Maprotiline?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant with antihistaminic and anticholinergic activity. Combined with azelastine, which can cause drowsiness, the sedative effect may be increased and psychomotor performance impaired.
How serious is the interaction between Azelastine-fluticasone and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on additive drowsiness and avoidance of driving or hazardous tasks until tolerance is established. Consider fluticasone alone if sedation is problematic.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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