Drug interactions
Azelastine-fluticasone + Methocarbamol
Severity: Moderate
Azelastine-fluticasone and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol is a centrally acting muscle relaxant that causes drowsiness, and azelastine may add to this. Together they can increase sedation and dizziness.
What this interaction means in plain words
Azelastine-fluticasone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Advise the patient about additive drowsiness and caution with driving or machinery. Consider fluticasone alone if sedation is bothersome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Methocarbamol
Frequently asked questions
Can I take Azelastine-fluticasone with Methocarbamol?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methocarbamol is a centrally acting muscle relaxant that causes drowsiness, and azelastine may add to this. Together they can increase sedation and dizziness.
How serious is the interaction between Azelastine-fluticasone and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient about additive drowsiness and caution with driving or machinery. Consider fluticasone alone if sedation is bothersome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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