Drug interactions
Azelastine-fluticasone + Quetiapine
Severity: Minor
Azelastine-fluticasone and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may add to the sedation caused by quetiapine. Systemic azelastine exposure from the nasal spray is low, so the effect is generally small.
What this interaction means in plain words
Azelastine-fluticasone and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from antihistaminic effects.
What to do
Warn patients about possible increased drowsiness and advise caution with driving. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Quetiapine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine may add to the sedation caused by quetiapine. Systemic azelastine exposure from the nasal spray is low, so the effect is generally small.
How serious is the interaction between Azelastine-fluticasone and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about possible increased drowsiness and advise caution with driving. No dose change is usually required.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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