Drug interactions
Azelastine-fluticasone + Secobarbital
Severity: Moderate
Azelastine-fluticasone and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is a barbiturate hypnotic, and azelastine may add to its sedative and psychomotor effects. Nasal dosing limits systemic azelastine exposure, but the combined drowsiness can still matter.
What this interaction means in plain words
Azelastine-fluticasone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A enhancement and H1 antagonism.
What to do
Avoid alcohol and other sedatives, and counsel about impaired driving. Use the lowest effective secobarbital dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Secobarbital?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital is a barbiturate hypnotic, and azelastine may add to its sedative and psychomotor effects. Nasal dosing limits systemic azelastine exposure, but the combined drowsiness can still matter.
How serious is the interaction between Azelastine-fluticasone and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid alcohol and other sedatives, and counsel about impaired driving. Use the lowest effective secobarbital dose.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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