Drug interactions
Azelastine-fluticasone + Thioridazine
Severity: Minor
Azelastine-fluticasone and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may add to the sedation caused by thioridazine. Thioridazine carries a major QT risk, but the nasal spray adds little systemic exposure and no important QT effect is established.
What this interaction means in plain words
Azelastine-fluticasone and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from antihistaminic and phenothiazine effects.
What to do
Counsel patients on additive drowsiness. Continue usual ECG and electrolyte monitoring for thioridazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Thioridazine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine may add to the sedation caused by thioridazine. Thioridazine carries a major QT risk, but the nasal spray adds little systemic exposure and no important QT effect is established.
How serious is the interaction between Azelastine-fluticasone and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on additive drowsiness. Continue usual ECG and electrolyte monitoring for thioridazine.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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