Drug interactions
Azilsartan + Etodolac
Severity: Moderate
Azilsartan and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce the antihypertensive effect of azilsartan. In older or volume-depleted patients the combination may also cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Azilsartan and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins, so afferent arteriolar constriction combined with angiotensin receptor blockade lowers glomerular filtration and blunts blood pressure control.
What to do
Maintain hydration and monitor serum creatinine, potassium and blood pressure, especially at initiation. Avoid the combination in dehydrated or elderly patients with renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Etodolac?
MediHelp rates the interaction as moderate. Azilsartan and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce the antihypertensive effect of azilsartan. In older or volume-depleted patients the combination may also cause acute kidney injury and hyperkalemia.
How serious is the interaction between Azilsartan and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor serum creatinine, potassium and blood pressure, especially at initiation. Avoid the combination in dehydrated or elderly patients with renal impairment where possible.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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