Drug interactions
Azilsartan + Ketoprofen
Severity: Moderate
Azilsartan and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can reduce the antihypertensive effect of azilsartan and, together with an angiotensin receptor blocker, may worsen kidney function, especially in elderly or volume-depleted patients. Potassium may also rise.
What this interaction means in plain words
Azilsartan and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins while ARBs lower efferent arteriolar tone, together reducing glomerular filtration pressure and potassium excretion.
What to do
Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting or changing ketoprofen. Avoid regular NSAID use in high-risk patients, especially those also on diuretics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Ketoprofen?
MediHelp rates the interaction as moderate. Azilsartan and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen can reduce the antihypertensive effect of azilsartan and, together with an angiotensin receptor blocker, may worsen kidney function, especially in elderly or volume-depleted patients. Potassium may also rise.
How serious is the interaction between Azilsartan and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting or changing ketoprofen. Avoid regular NSAID use in high-risk patients, especially those also on diuretics.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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