Drug interactions
Azilsartan + Voclosporin
Severity: Major
Azilsartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can cause nephrotoxicity and hyperkalemia, and azilsartan can also reduce glomerular filtration and raise potassium. Together they increase the risk of renal function decline and hyperkalemia.
What this interaction means in plain words
Azilsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxic hemodynamic effects (calcineurin inhibitor afferent vasoconstriction plus ARB efferent dilation) and additive potassium retention.
What to do
Monitor serum creatinine, eGFR and potassium frequently, especially at initiation and dose changes. Reduce the voclosporin dose or stop the ARB if renal function falls or potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan and Voclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Azilsartan with Voclosporin?
MediHelp rates the interaction as major. Azilsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin can cause nephrotoxicity and hyperkalemia, and azilsartan can also reduce glomerular filtration and raise potassium. Together they increase the risk of renal function decline and hyperkalemia.
How serious is the interaction between Azilsartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, eGFR and potassium frequently, especially at initiation and dose changes. Reduce the voclosporin dose or stop the ARB if renal function falls or potassium rises.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
