Drug interactions
Azilsartan-chlorthalidone + Carbidopa
Severity: Moderate
Azilsartan-chlorthalidone and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa is usually given with levodopa, and levodopa therapy can cause orthostatic hypotension. In patients on azilsartan and chlorthalidone the blood pressure lowering may be amplified, causing dizziness or falls.
What this interaction means in plain words
Azilsartan-chlorthalidone and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects, since levodopa formed with carbidopa causes vasodilation and autonomic effects that add to the antihypertensive drugs.
What to do
Check supine and standing blood pressure when starting or adjusting carbidopa-levodopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Carbidopa
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Carbidopa?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa is usually given with levodopa, and levodopa therapy can cause orthostatic hypotension. In patients on azilsartan and chlorthalidone the blood pressure lowering may be amplified, causing dizziness or falls.
How serious is the interaction between Azilsartan-chlorthalidone and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check supine and standing blood pressure when starting or adjusting carbidopa-levodopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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