Drug interactions
Azilsartan-chlorthalidone + Celecoxib
Severity: Moderate
Azilsartan-chlorthalidone and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as celecoxib blunt the antihypertensive effect of ARBs and diuretics and promote sodium and fluid retention. In combination with a diuretic and an ARB, they raise the risk of acute kidney injury, especially in older or volume-depleted patients, and may cause hyperkalemia.
What this interaction means in plain words
Azilsartan-chlorthalidone and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis reduces afferent arteriolar dilation and sodium excretion, which counters antihypertensive effects and compromises glomerular filtration when combined with ARB and diuretic.
What to do
Use the lowest effective NSAID dose for the shortest time, and ensure adequate hydration. Monitor blood pressure, creatinine and potassium, particularly in the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Celecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Celecoxib?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as celecoxib blunt the antihypertensive effect of ARBs and diuretics and promote sodium and fluid retention. In combination with a diuretic and an ARB, they raise the risk of acute kidney injury, especially in older or volume-depleted patients, and may cause hyperkalemia.
How serious is the interaction between Azilsartan-chlorthalidone and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, and ensure adequate hydration. Monitor blood pressure, creatinine and potassium, particularly in the first weeks.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
