Drug interactions
Azilsartan-chlorthalidone + Chlorothiazide
Severity: Moderate
Azilsartan-chlorthalidone and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide is a thiazide diuretic and duplicates the action of chlorthalidone. Together they increase the risk of hypokalemia, hyponatremia, volume depletion and hypotension without clear added benefit.
What this interaction means in plain words
Azilsartan-chlorthalidone and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive inhibition of the distal tubule sodium-chloride cotransporter.
What to do
Avoid using two thiazide-type diuretics together. If a combination is used for a specific reason, monitor electrolytes and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Chlorothiazide?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide is a thiazide diuretic and duplicates the action of chlorthalidone. Together they increase the risk of hypokalemia, hyponatremia, volume depletion and hypotension without clear added benefit.
How serious is the interaction between Azilsartan-chlorthalidone and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together. If a combination is used for a specific reason, monitor electrolytes and renal function closely.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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