Drug interactions
Azilsartan-chlorthalidone + Diflunisal
Severity: Moderate
Azilsartan-chlorthalidone and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal, an NSAID, can blunt the blood-pressure lowering effect of azilsartan and chlorthalidone. Together with an ARB and a diuretic it raises the risk of renal function deterioration, particularly in older or volume-depleted patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium retention and reduced glomerular perfusion, opposing ARB and diuretic action.
What to do
Use the lowest effective dose for the shortest time, ensure hydration, and monitor blood pressure, serum creatinine and potassium. Choose a non-NSAID analgesic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Diflunisal?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal, an NSAID, can blunt the blood-pressure lowering effect of azilsartan and chlorthalidone. Together with an ARB and a diuretic it raises the risk of renal function deterioration, particularly in older or volume-depleted patients.
How serious is the interaction between Azilsartan-chlorthalidone and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time, ensure hydration, and monitor blood pressure, serum creatinine and potassium. Choose a non-NSAID analgesic if feasible.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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