Drug interactions
Azilsartan-chlorthalidone + Folic acid
Severity: Minor
Azilsartan-chlorthalidone and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may modestly increase renal folate loss, but clinically significant folate deficiency is not expected in well-nourished patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Folic acid belongs to Miscellaneous.
Why it happens
Possible increased urinary folate excretion; mechanism not firmly established.
What to do
No action is needed routinely; check folate status only in patients with other risk factors for deficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Folic acid?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may modestly increase renal folate loss, but clinically significant folate deficiency is not expected in well-nourished patients.
How serious is the interaction between Azilsartan-chlorthalidone and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed routinely; check folate status only in patients with other risk factors for deficiency.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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