Drug interactions
Azilsartan-chlorthalidone + Irbesartan
Severity: Major
Azilsartan-chlorthalidone and Irbesartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azilsartan is already an ARB, so adding irbesartan is duplicate renin-angiotensin blockade. Dual ARB therapy increases the risk of hypotension, hyperkalemia and renal impairment without proven benefit.
What this interaction means in plain words
Azilsartan-chlorthalidone and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade producing additive effects on aldosterone suppression, renal hemodynamics and blood pressure.
What to do
Avoid combining two ARBs and use a single agent. If this has occurred, stop one and monitor potassium, creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Azilsartan-chlorthalidone
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Irbesartan?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azilsartan is already an ARB, so adding irbesartan is duplicate renin-angiotensin blockade. Dual ARB therapy increases the risk of hypotension, hyperkalemia and renal impairment without proven benefit.
How serious is the interaction between Azilsartan-chlorthalidone and Irbesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs and use a single agent. If this has occurred, stop one and monitor potassium, creatinine and blood pressure.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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