Drug interactions
Azilsartan-chlorthalidone + Isoproterenol
Severity: Moderate
Azilsartan-chlorthalidone and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both chlorthalidone and isoproterenol can lower serum potassium. Hypokalemia increases the risk of arrhythmias, particularly with a strong beta-agonist.
What this interaction means in plain words
Azilsartan-chlorthalidone and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Beta-2 stimulation shifts potassium into cells while the diuretic increases urinary potassium loss.
What to do
Monitor serum potassium and ECG in patients receiving isoproterenol with chlorthalidone, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Isoproterenol
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Isoproterenol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both chlorthalidone and isoproterenol can lower serum potassium. Hypokalemia increases the risk of arrhythmias, particularly with a strong beta-agonist.
How serious is the interaction between Azilsartan-chlorthalidone and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG in patients receiving isoproterenol with chlorthalidone, and replace potassium as needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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