Drug interactions
Azilsartan-chlorthalidone + Ketoprofen
Severity: Moderate
Azilsartan-chlorthalidone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can blunt the antihypertensive effect of azilsartan and chlorthalidone. The combination of an NSAID, ARB and diuretic increases the risk of acute kidney injury, especially in older or volume-depleted patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins, causing sodium retention and reduced renal perfusion in the presence of angiotensin blockade and diuresis.
What to do
Use the lowest NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Ketoprofen?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen can blunt the antihypertensive effect of azilsartan and chlorthalidone. The combination of an NSAID, ARB and diuretic increases the risk of acute kidney injury, especially in older or volume-depleted patients.
How serious is the interaction between Azilsartan-chlorthalidone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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