Drug interactions
Azilsartan-chlorthalidone + L-methylfolate
Severity: Minor
Azilsartan-chlorthalidone and L-methylfolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may modestly increase renal folate loss. Clinical significance is unclear and likely small.
What this interaction means in plain words
Azilsartan-chlorthalidone and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; L-methylfolate belongs to Miscellaneous.
Why it happens
Increased urinary excretion of folate with thiazide diuresis; the mechanism is not firmly established.
What to do
No routine action is needed. Consider checking folate status if deficiency is suspected during long-term therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of L-methylfolate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with L-methylfolate?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may modestly increase renal folate loss. Clinical significance is unclear and likely small.
How serious is the interaction between Azilsartan-chlorthalidone and L-methylfolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Consider checking folate status if deficiency is suspected during long-term therapy.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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