Drug interactions
Azilsartan-chlorthalidone + Levodopa
Severity: Moderate
Azilsartan-chlorthalidone and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure and cause orthostatic hypotension, which may be enhanced when it is given with an antihypertensive combination of an ARB and a diuretic. Patients may experience dizziness or falls, especially when starting or increasing therapy.
What this interaction means in plain words
Azilsartan-chlorthalidone and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from dopaminergic vasodilation and autonomic effects of levodopa together with diuretic volume reduction and angiotensin receptor blockade.
What to do
Monitor supine and standing blood pressure when starting or adjusting either drug, and counsel patients to rise slowly. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Levodopa, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Levodopa?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure and cause orthostatic hypotension, which may be enhanced when it is given with an antihypertensive combination of an ARB and a diuretic. Patients may experience dizziness or falls, especially when starting or increasing therapy.
How serious is the interaction between Azilsartan-chlorthalidone and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or adjusting either drug, and counsel patients to rise slowly. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
