Drug interactions
Azilsartan-chlorthalidone + Mesalamine
Severity: Minor
Azilsartan-chlorthalidone and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone may compete with mesalamine metabolites for renal tubular secretion, potentially raising their levels slightly. Clinical impact is expected to be small.
What this interaction means in plain words
Azilsartan-chlorthalidone and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Competition for organic anion transport in the renal tubule reduces elimination of the acidic compounds.
What to do
No routine action is needed. Monitor renal function, as mesalamine can be nephrotoxic and diuretics may add to volume-related renal stress.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Mesalamine
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Mesalamine?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone may compete with mesalamine metabolites for renal tubular secretion, potentially raising their levels slightly. Clinical impact is expected to be small.
How serious is the interaction between Azilsartan-chlorthalidone and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor renal function, as mesalamine can be nephrotoxic and diuretics may add to volume-related renal stress.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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